RAF Typhoon FGR4s have joined forces with France's air force in a combined operation against an hidden munitions depot in Syria used by the Daesh militant organization, according to the UK's MoD.
The facility, located using surveillance, was thought to be housing weapons and explosive materials, the statement said, and was located in mountains just north of the historic site of Palmyra in central Syria.
"The RAF jets used precision-guided Paveway IV munitions to target a number of approach shafts leading to the facility... initial indications indicate the objective was successfully hit," officials stated.
There was no sign of any civilian impact in the operation late on Saturday and each participating jet returned safely, the ministry further stated.
The British jets were supported by a Voyager tanker plane.
The Islamic State group - referred to as the so-called Islamic State - enforced jihadist rule over large swathes of Syria and Iraq before its territorial defeat in 2019.
"This strike shows the UK's leading role, and determination to stand shoulder to shoulder with our partners, to stamp out any revival of IS and their harmful and extremist ideologies in the Middle East," Britain's Defence Chief the Defence Secretary remarked.
British military aircraft have conducted overwatch operations over Syrian airspace to "prevent any efforts to regroup" of Islamic State after its routing at the Baghuz confrontation in 2019, the ministry said.
"I must thank all the members of the UK armed forces involved in this operation for their professionalism and their valour," the Defence Secretary added. "They were part of thousands of British personnel deployed over the festive period. This action, to eliminate militants who threaten our safety, shows how our armed forces are always on standby, continuously, keeping Britain secure at home and strong abroad."
In December, the US military conducted what it called a "massive strike" on IS targets in the country, following an attack claimed the lives of two American soldiers and a local interpreter in the Palmyra area.
The United Nations reports Daesh still boasts roughly 5-7 thousand fighters in both countries.